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Cautions: Ineffective for male hypersexuality in chronic alcoholism (relevance to prostate cancer not known); blood counts initially and throughout treatment; see also under Side-Effects below); monitor adrenocortical function regularly; diabetes mellitus.

Contra-indications: (do not apply in prostate cancer) hepatic disease, sever diabetes (with vascular changes); sickle-cell anemia, malignant or wasting disease, severe depression, history of thrombo-embolic disorders; youths under 18 years (may arrest bone maturation and testicular development).

Side-Efeects: Fatique and lassitude, breathlessness, weight changes, reduced sebum production (may clear acne), changes in hair pattern, gynaecomastia (rarely leading to galactorrhea and bengin breast nodules); rarely hypersensitivity reactions, rash and osteoporosis; inhibition of spermatogencesis (see notes above); hepatotoxicity reported (including jaundice, hepatitis and hepatic failure usually in men given 200-300 mg daily for prostatic cancer.

Dose: Male hypersexuality, 50 mg twice daily after food.