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Indications : Prostate cancer, see notes above
Cautions: Hepatic impairment (Appendix 2), also
consider periodic liver function tests;
Interactions : Appendix 1 (Bicalutamide).
Side-Effects: Dyspepsia, nausea, vomiting, diarrhea,
abdominal pain, asthenia, depression, gynaecomastia, breast tenderness,
decreated libido, hot flushesh, alopecia, hirsutism, prutius,
dry skin, haematuria, cholestasis and jaundice (very rarely hepatic
failure); rarely cardiovascular disorders (including angina, heart
failure, conduction defects, arrhythmias and ECG changes); also
reported, other gastro-intestional disorders, oedema, chest pain,
dyspnoea, dry mouth headache, dizziness, insomnia, drowsiness,
impotence, nocturia, rash, sweating, hyperglycaemina, weight changes;
pelvic pain, anaemia, thrombocytopenia.
Dose: with orchidectomy or gonadoerlin therapy,
50 mg daily (in gonadorelin therapy, started 3 prostate cancer,
150 mg once daily.