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SOMATOSTATIN : It is a synthetic cyclic tetredecapeptide having the structure of the hypothalamic hormone that inhibits the release of growth hormone.

Indication: Acute severe bleeding oesophageal varices, acute upper GI bleeding resulting from gastric/duodenal ulcers and haemorrhagic gastritis. Intestinal and pancreatic fistula. Hypersecretory endocrine tumours of the intestinaltract.

Dosage: Acute bleeding oesophageal varices : IV bolus of 250 mcg over 1 minute, followed by 6 mg/24 Hr continuous infusion for 5 days. In case of interruption new IV bolus 250 mcg should be given. Uper GI bleeding from gastric/duodenal ulcers: IV blous of 250 mcg followed by 3 mg 12 hourly continuous infusion for 2-5 days.

Intestinal & pancreatic fistulae : IV bolus not required. Infusion 6 mgday may be required up to 14 days. After closure of fistulae infusion should be at half-dosage for the next 48 hrs.

Contraindications: Hypersensitivity.

Special precautions: Blood glucose levels must be monitored, particularly in diabetics. In patients with fistual taper the dose after closure of the fistulae.

Side effects: Abdominal discomfort, flushing, nausea and bradycardia, stetorrhea, dyspepsia, hypochlorhydria, cholelithiasis, mild watery diarra.

Drug interactions : None reported.