Tybar
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ORAL TYPHOID VACCIN Contains the attentuated strain Ty21a of S.typhi. The attenuation of the virulence of this strain is due to the absence of the enzyme Uridine diphosphate galac-tose-4 epimerase which is essential for the production of the lipopolysaccharide'O'antigen.The absence of this enzyme makes Ty21a avirulent but highly immunogenic. This oral vaccine acts in a way similar to the typhoid bacillus itself, but instead of causing typhoid fever, it gives immunity against it.
Indication: Prophylactic immunisation oildren over 6 years against typhoid fever. One capsule on days 1,3 and 5 irrespective of age. It is to be taken 1 hour before a meal with cold or lukewarm milk or water. Contraindications Acute febrile illness, acute intestinal infection, congenital or acquired immuno-Sulphonamirjes known to be active against S.typhi should not be given concomitantly.
Side Effect: Fever & mild gastro-iniestinal effects.
Drug Interactions : Failure of vaccination with high dose systemic corticosteroid therapy, immu-nosuppressive therapy and irradiation.