OESTROGEN: Secretion starts form the graffian folicle under the influence of FSH and concentration in blood rise gradually during follcular phase Due to the modest FSH surge, estrogen further rise transiently. After ovulation corpus luteum continues to screte estrogens till about two days before mestruation. Estrogens exercise feed back inhibition of FSH (also LH at higher concentrations by direct action on pituitary as well as through hypothalamus. In oestrogen. Thus synthetic compounds of oestrogen are useful in the treatment of post menopasusal deficiency states particularly when active ovaries have been removed surgically & the abrupt hormonal with drawal is there.

Indications: Menopasula syndrome, senil vaginitis, delayed puberty in gills. Postmenopausal oetoporoisi. Cntraceptive. Dysmenorrhoea. Acne hrisutism. Functional uterine bleeding. Suppresion of lactation. Carcinoma prostate, carcinoma breast.

Contra Indications: Pregnancy lactation undiagnosed vaginal bleeding. Cardiovascular or cerebrovascular disorders e.g thrombophlebitis thrombo-embolic processes. Severe hepatic impairment. hypertension. Herpes gestations. Rotor syndrom, Dubin-jonson syndrome. Prophyria. Endometrial hyprplasia. Hyperlipoproteinaemia. Suspected estrogen dependent neoplasia tumours.

Special Precautions: Epilepsy, migraine asthma cardiac or renal disease. Discontinue if cancer progression or hypercalcaemia occur. May cause salt & fluied retention chronic mastits abnoraml mammorgram lempnding major surgery.

Side effects: Suppression of libido, hyneacomastia & faminization in males. Endometrial carcinoma. Breast cancer Beningn hepatomas. Fusion of epipyses & reduction of adult stature whein give to children.

Drug Interaction: Rifampicin barbiturates and phenytoin increase rate of metabolism reduce effectiveness of antcoagulants and enhance activity of phenytion.