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TIBOLONE: Tibolone is innovative synthetic steroid which possess a combination of estrogenic progestogenic & wak andorgenic activites it offers an attractive alternative to conventional hormaonal therapy for the alleviation of post-menopausal climateric & restores plasma-endorphin level sin post-monopausal women& women & act centrally to affect the thermo-regulatory system.

Indications: Vasomotor symptoms resulting from a natural or surgical menopause.

Dosage: 2.5 mg daily.

Contra Indications: Hormone-dependent tumors cardiovascular or cerebrovasular disease uninvestigated virginal bleeding, severe liver disease.

Side Effects: Weight gain dizziness seborrheic dermaitis, Pre tibial edema facial hari growth leevated serum alanine aminotrasferase and aspartate aminnotrasfearese levels, vaginla bleeding.

Special Precautions: Renal dysfunction epilepsy diabetic patients & hypercholesterolemia. Drug should note use in permenopasual women or in women within 1 years of the menopause.

Pregnancy: Contaminated Lactation: Contraindicated

Drug Interaction: Tiburon activity may be reduced and metabolism increase in women akin ifampicin or anticonvulsant such as phenytoin phenobarbitone or carbamazepin. In diabetics the requirements for insulin or other hypoglycemic agents may increase with conocmitant tibolone thearpy.